Dr Marc Bartoli is a recognized expert in physiopathological studies of muscular dystrophies and gene transfer. He has particular experience on limb-girdle muscular dystrophies. He has undertaken several studies on the function and physiopathology of the proteins involved in these diseases and successfully demonstrated the efficiency and safety of gene transfer for LGMD2A, B and D. Marc has also developed several new tools to study the function of calpain 3 and dysferlin in vitro and in vivo and methods for monitoring gene transfer efficiency. Finally, Marc has acquired new bioinformatics skills to handle the design of DNA-chip and the data analysis of those experiments.
Marc is involved in the WP3 ‘Design, production and technical validation of candidate genes targeted chips’, in particular he will help to choose the more relevant candidate genes for LGMDs and design the DNA-chip.