James Tidball

Distinguished Professor

United States of America

Jim received his Ph.D. at Dalhousie University and then received post-doctoral training at Duke University where he studied protein complexes at the cell membrane of muscle cells. The foci of research in his lab over the last 25 years have been: 1) the role of immune cells in regulating muscle damage and regeneration in muscular dystrophy, and 2) mechanisms through which nitric oxide synthase deficiency contributes to the pathology of muscular dystrophy. Previous work from his lab showed that restoration of nitric oxide synthase to dystrophic muscle ameliorates pathology in muscular dystrophy and established the role of myeloid cells in promoting both muscle damage and regeneration in muscular dystrophy. Current research is directed toward using immune cells to target therapeutic molecules to dystrophic muscle and exploring pharmacological interventions to modify the immune response to muscular dystrophy.