Professor Neuromuscular Diseases Group
After several years in general practice he moved to the USA and did his PhD on hummingbird flight. After that he returned to the UK with a lecturer post at the Royal Veterinary College where he first became involved in DMD research. From 1995 he has been based at the Imperial College.
His research over the last 18 years has focussed on methods of somatic gene transfer with particular emphasis on DMD and the generation and analysis of genetically modified mice. Dominic’s laboratory is examining the factors influencing the efficiency of local and systemic administration of antisense oligos in the mdx mouse model of DMD. They not only assess dystrophin expression by RT-PCR, western blots and immunostaining but also are fully equipped to assess in vivo and in vitro muscle function.